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Thursday night after a brief argument between Smith and at least one Chargers player at the San Diego 8. Smith appeared to shove away umpire Garth DeFelice while the official attempted to keep Smith out of the dispute, and DeFelice immediately threw a flag.

San Francisco linebacker Travis LaBoy made the tackle on the play, but also left with a knee injury.

The ejection of Smith, who has started 153 straight games, occurred shortly after San Diego's defense stopped the 49ers on fourth down inside the 1, maintaining the Chargers' 7-0 lead.